SuicidDentistV1, Main, Exploration, bibRecord, 000038

Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.

Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039

Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.

Source :

European journal of pharmacology [ 1879-0712 ] ; 2020.

RBID : pubmed:32726654

Descripteurs français

KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Activation enzymatique (MeSH), Alimentation riche en graisse (MeSH), Animaux (MeSH), Autophagie (effets des médicaments et des substances chimiques), Facteurs âges (MeSH), Foie (anatomopathologie), Foie (effets des médicaments et des substances chimiques), Foie (enzymologie), Lignée cellulaire (MeSH), Modèles animaux de maladie humaine (MeSH), Mâle (MeSH), Métabolisme lipidique (effets des médicaments et des substances chimiques), Neurégulines (pharmacologie), Souris de lignée C57BL (MeSH), Stéatose hépatique non alcoolique (anatomopathologie), Stéatose hépatique non alcoolique (enzymologie), Stéatose hépatique non alcoolique (prévention et contrôle), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH).
MESH :
- anatomopathologie : Foie, Stéatose hépatique non alcoolique.
- effets des médicaments et des substances chimiques : Autophagie, Foie, Métabolisme lipidique.
- enzymologie : Foie, Stéatose hépatique non alcoolique.
- métabolisme : AMP-Activated Protein Kinases, Sérine-thréonine kinases TOR.
- pharmacologie : Neurégulines.
- prévention et contrôle : Stéatose hépatique non alcoolique.
- Activation enzymatique, Alimentation riche en graisse, Animaux, Facteurs âges, Lignée cellulaire, Modèles animaux de maladie humaine, Mâle, Souris de lignée C57BL, Transduction du signal.

English descriptors

KwdEn :
- AMP-Activated Protein Kinases (metabolism), Age Factors (MeSH), Animals (MeSH), Autophagy (drug effects), Cell Line (MeSH), Diet, High-Fat (MeSH), Disease Models, Animal (MeSH), Enzyme Activation (MeSH), Lipid Metabolism (drug effects), Liver (drug effects), Liver (enzymology), Liver (pathology), Male (MeSH), Mice, Inbred C57BL (MeSH), Neuregulins (pharmacology), Non-alcoholic Fatty Liver Disease (enzymology), Non-alcoholic Fatty Liver Disease (pathology), Non-alcoholic Fatty Liver Disease (prevention & control), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , metabolism : AMP-Activated Protein Kinases, TOR Serine-Threonine Kinases.
- drug effects : Autophagy, Lipid Metabolism, Liver.
- enzymology : Liver, Non-alcoholic Fatty Liver Disease.
- pathology : Liver, Non-alcoholic Fatty Liver Disease.
- chemical , pharmacology : Neuregulins.
- prevention & control : Non-alcoholic Fatty Liver Disease.
- Age Factors, Animals, Cell Line, Diet, High-Fat, Disease Models, Animal, Enzyme Activation, Male, Mice, Inbred C57BL, Signal Transduction.

Abstract

Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that exerts beneficial metabolic effects on insulin resistance and hepatic steatosis. Autophagy is a mechanism that is essential for preventing hepatic steatosis. The aim of this study was to explore whether Nrg4 ameliorates hepatic steatosis by inducing autophagy. Aged C57BL/6 mice were maintained on a high fat diet with or without Nrg4 intervention for 3 months. Lipid accumulation in the liver was investigated. Autophagy related protein levels along with related signaling pathways that regulate autophagy were evaluated. In addition, the effects of Nrg4 on autophagy were also determined in cultured L-02 cells. Nrg4 decreased high-fat induced intrahepatic lipid content both in vivo and in vitro. Autophagy level in the liver also decreased in obese mice and Nrg4 intervention reactivated autophagy. Further, Nrg4 intervention was found to have activated autophagy via the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway. Moreover, when the AMPK/mTOR pathway was suppressed or autophagy was inhibited, the beneficial effects of Nrg4 intervention on hepatic steatosis were diminished. These results indicated that Nrg4 intervention attenuated hepatic steatosis by promoting autophagy in the liver of aged obese mice. Additionally, Nrg4 induced autophagy via the AMPK/mTOR signaling pathway.

DOI: 10.1016/j.ejphar.2020.173350
PubMed: 32726654

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000028
to stream Main, to step Curation: 000028

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.</title>
<author><name sortKey="Zhu, Biao" sort="Zhu, Biao" uniqKey="Zhu B" first="Biao" last="Zhu">Biao Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: zhubiao2015smu@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mei, Wen" sort="Mei, Wen" uniqKey="Mei W" first="Wen" last="Mei">Wen Mei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, Nanhai District People's Hospital of Foshan, Foping Road 40, Foshan, 528200, Guangdong Province, China. Electronic address: xiaomeiwen@outlook.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Endocrinology, Nanhai District People's Hospital of Foshan, Foping Road 40, Foshan, 528200, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiao, Ting" sort="Jiao, Ting" uniqKey="Jiao T" first="Ting" last="Jiao">Ting Jiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: 58322845@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Shuo" sort="Yang, Shuo" uniqKey="Yang S" first="Shuo" last="Yang">Shuo Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 15010358798@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Xiaoli" sort="Xu, Xiaoli" uniqKey="Xu X" first="Xiaoli" last="Xu">Xiaoli Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 946995045@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yu, Hanying" sort="Yu, Hanying" uniqKey="Yu H" first="Hanying" last="Yu">Hanying Yu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dicry@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 574515514@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Shuqin" sort="Guo, Shuqin" uniqKey="Guo S" first="Shuqin" last="Guo">Shuqin Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 280728672@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meng, Biying" sort="Meng, Biying" uniqKey="Meng B" first="Biying" last="Meng">Biying Meng</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: m847501591@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Lisheng" sort="Zhao, Lisheng" uniqKey="Zhao L" first="Lisheng" last="Zhao">Lisheng Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dentist_zhao@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Mingjuan" sort="He, Mingjuan" uniqKey="He M" first="Mingjuan" last="He">Mingjuan He</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: mingjuan-he@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dong, Keming" sort="Dong, Keming" uniqKey="Dong K" first="Keming" last="Dong">Keming Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: dentistmrdong@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Hongyan" sort="Guo, Hongyan" uniqKey="Guo H" first="Hongyan" last="Guo">Hongyan Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: ghyfmmu@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Ximin" sort="Guo, Ximin" uniqKey="Guo X" first="Ximin" last="Guo">Ximin Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: guoxim@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Haisong" sort="Zhang, Haisong" uniqKey="Zhang H" first="Haisong" last="Zhang">Haisong Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: hdfyzhs1665@sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dang, Ruijie" sort="Dang, Ruijie" uniqKey="Dang R" first="Ruijie" last="Dang">Ruijie Dang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: powerdang@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiang, Guangda" sort="Xiang, Guangda" uniqKey="Xiang G" first="Guangda" last="Xiang">Guangda Xiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: guangda64@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wen, Ning" sort="Wen, Ning" uniqKey="Wen N" first="Ning" last="Wen">Ning Wen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: wenningchn@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32726654</idno>
<idno type="pmid">32726654</idno>
<idno type="doi">10.1016/j.ejphar.2020.173350</idno>
<idno type="wicri:Area/Main/Corpus">000028</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000028</idno>
<idno type="wicri:Area/Main/Curation">000028</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000028</idno>
<idno type="wicri:Area/Main/Exploration">000028</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.</title>
<author><name sortKey="Zhu, Biao" sort="Zhu, Biao" uniqKey="Zhu B" first="Biao" last="Zhu">Biao Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: zhubiao2015smu@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mei, Wen" sort="Mei, Wen" uniqKey="Mei W" first="Wen" last="Mei">Wen Mei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, Nanhai District People's Hospital of Foshan, Foping Road 40, Foshan, 528200, Guangdong Province, China. Electronic address: xiaomeiwen@outlook.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Endocrinology, Nanhai District People's Hospital of Foshan, Foping Road 40, Foshan, 528200, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiao, Ting" sort="Jiao, Ting" uniqKey="Jiao T" first="Ting" last="Jiao">Ting Jiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: 58322845@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Shuo" sort="Yang, Shuo" uniqKey="Yang S" first="Shuo" last="Yang">Shuo Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 15010358798@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Xiaoli" sort="Xu, Xiaoli" uniqKey="Xu X" first="Xiaoli" last="Xu">Xiaoli Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 946995045@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yu, Hanying" sort="Yu, Hanying" uniqKey="Yu H" first="Hanying" last="Yu">Hanying Yu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dicry@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 574515514@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Shuqin" sort="Guo, Shuqin" uniqKey="Guo S" first="Shuqin" last="Guo">Shuqin Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 280728672@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meng, Biying" sort="Meng, Biying" uniqKey="Meng B" first="Biying" last="Meng">Biying Meng</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: m847501591@qq.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Lisheng" sort="Zhao, Lisheng" uniqKey="Zhao L" first="Lisheng" last="Zhao">Lisheng Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dentist_zhao@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Mingjuan" sort="He, Mingjuan" uniqKey="He M" first="Mingjuan" last="He">Mingjuan He</name>
<affiliation wicri:level="1"><nlm:affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: mingjuan-he@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province</wicri:regionArea>
<wicri:noRegion>Guangdong Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dong, Keming" sort="Dong, Keming" uniqKey="Dong K" first="Keming" last="Dong">Keming Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: dentistmrdong@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Hongyan" sort="Guo, Hongyan" uniqKey="Guo H" first="Hongyan" last="Guo">Hongyan Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: ghyfmmu@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Ximin" sort="Guo, Ximin" uniqKey="Guo X" first="Ximin" last="Guo">Ximin Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: guoxim@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039</wicri:regionArea>
<wicri:noRegion>100039</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Haisong" sort="Zhang, Haisong" uniqKey="Zhang H" first="Haisong" last="Zhang">Haisong Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: hdfyzhs1665@sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dang, Ruijie" sort="Dang, Ruijie" uniqKey="Dang R" first="Ruijie" last="Dang">Ruijie Dang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: powerdang@126.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province</wicri:regionArea>
<wicri:noRegion>Hebei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiang, Guangda" sort="Xiang, Guangda" uniqKey="Xiang G" first="Guangda" last="Xiang">Guangda Xiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: guangda64@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wen, Ning" sort="Wen, Ning" uniqKey="Wen N" first="Ning" last="Wen">Ning Wen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: wenningchn@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853</wicri:regionArea>
<wicri:noRegion>100853</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of pharmacology</title>
<idno type="eISSN">1879-0712</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term>
<term>Age Factors (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Autophagy (drug effects)</term>
<term>Cell Line (MeSH)</term>
<term>Diet, High-Fat (MeSH)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Enzyme Activation (MeSH)</term>
<term>Lipid Metabolism (drug effects)</term>
<term>Liver (drug effects)</term>
<term>Liver (enzymology)</term>
<term>Liver (pathology)</term>
<term>Male (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Neuregulins (pharmacology)</term>
<term>Non-alcoholic Fatty Liver Disease (enzymology)</term>
<term>Non-alcoholic Fatty Liver Disease (pathology)</term>
<term>Non-alcoholic Fatty Liver Disease (prevention & control)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term>
<term>Activation enzymatique (MeSH)</term>
<term>Alimentation riche en graisse (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Autophagie (effets des médicaments et des substances chimiques)</term>
<term>Facteurs âges (MeSH)</term>
<term>Foie (anatomopathologie)</term>
<term>Foie (effets des médicaments et des substances chimiques)</term>
<term>Foie (enzymologie)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Métabolisme lipidique (effets des médicaments et des substances chimiques)</term>
<term>Neurégulines (pharmacologie)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Stéatose hépatique non alcoolique (anatomopathologie)</term>
<term>Stéatose hépatique non alcoolique (enzymologie)</term>
<term>Stéatose hépatique non alcoolique (prévention et contrôle)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term>
<term>Stéatose hépatique non alcoolique</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term>
<term>Lipid Metabolism</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Autophagie</term>
<term>Foie</term>
<term>Métabolisme lipidique</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term>
<term>Stéatose hépatique non alcoolique</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver</term>
<term>Non-alcoholic Fatty Liver Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term>
<term>Non-alcoholic Fatty Liver Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Neurégulines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuregulins</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Non-alcoholic Fatty Liver Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Stéatose hépatique non alcoolique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Animals</term>
<term>Cell Line</term>
<term>Diet, High-Fat</term>
<term>Disease Models, Animal</term>
<term>Enzyme Activation</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Alimentation riche en graisse</term>
<term>Animaux</term>
<term>Facteurs âges</term>
<term>Lignée cellulaire</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris de lignée C57BL</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that exerts beneficial metabolic effects on insulin resistance and hepatic steatosis. Autophagy is a mechanism that is essential for preventing hepatic steatosis. The aim of this study was to explore whether Nrg4 ameliorates hepatic steatosis by inducing autophagy. Aged C57BL/6 mice were maintained on a high fat diet with or without Nrg4 intervention for 3 months. Lipid accumulation in the liver was investigated. Autophagy related protein levels along with related signaling pathways that regulate autophagy were evaluated. In addition, the effects of Nrg4 on autophagy were also determined in cultured L-02 cells. Nrg4 decreased high-fat induced intrahepatic lipid content both in vivo and in vitro. Autophagy level in the liver also decreased in obese mice and Nrg4 intervention reactivated autophagy. Further, Nrg4 intervention was found to have activated autophagy via the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway. Moreover, when the AMPK/mTOR pathway was suppressed or autophagy was inhibited, the beneficial effects of Nrg4 intervention on hepatic steatosis were diminished. These results indicated that Nrg4 intervention attenuated hepatic steatosis by promoting autophagy in the liver of aged obese mice. Additionally, Nrg4 induced autophagy via the AMPK/mTOR signaling pathway.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32726654</PMID>
<DateCompleted><Year>2021</Year>
<Month>05</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>05</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0712</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>884</Volume>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
<Day>05</Day>
</PubDate>
</JournalIssue>
<Title>European journal of pharmacology</Title>
<ISOAbbreviation>Eur J Pharmacol</ISOAbbreviation>
</Journal>
<ArticleTitle>Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.</ArticleTitle>
<Pagination><MedlinePgn>173350</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0014-2999(20)30442-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejphar.2020.173350</ELocationID>
<Abstract><AbstractText>Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that exerts beneficial metabolic effects on insulin resistance and hepatic steatosis. Autophagy is a mechanism that is essential for preventing hepatic steatosis. The aim of this study was to explore whether Nrg4 ameliorates hepatic steatosis by inducing autophagy. Aged C57BL/6 mice were maintained on a high fat diet with or without Nrg4 intervention for 3 months. Lipid accumulation in the liver was investigated. Autophagy related protein levels along with related signaling pathways that regulate autophagy were evaluated. In addition, the effects of Nrg4 on autophagy were also determined in cultured L-02 cells. Nrg4 decreased high-fat induced intrahepatic lipid content both in vivo and in vitro. Autophagy level in the liver also decreased in obese mice and Nrg4 intervention reactivated autophagy. Further, Nrg4 intervention was found to have activated autophagy via the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway. Moreover, when the AMPK/mTOR pathway was suppressed or autophagy was inhibited, the beneficial effects of Nrg4 intervention on hepatic steatosis were diminished. These results indicated that Nrg4 intervention attenuated hepatic steatosis by promoting autophagy in the liver of aged obese mice. Additionally, Nrg4 induced autophagy via the AMPK/mTOR signaling pathway.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Biao</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: zhubiao2015smu@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mei</LastName>
<ForeName>Wen</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology, Nanhai District People's Hospital of Foshan, Foping Road 40, Foshan, 528200, Guangdong Province, China. Electronic address: xiaomeiwen@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiao</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: 58322845@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Shuo</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 15010358798@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Xiaoli</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 946995045@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Hanying</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dicry@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ding</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: 574515514@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Shuqin</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: 280728672@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meng</LastName>
<ForeName>Biying</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China; Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: m847501591@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Lisheng</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: dentist_zhao@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Mingjuan</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The First School of Clinical Medicine, Southern Medical University, Shatai Nan Road 1023, Guangzhou, 510515, Guangdong Province, China. Electronic address: mingjuan-he@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Keming</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: dentistmrdong@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Hongyan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: ghyfmmu@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Ximin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Yongding Road 69, Beijing, 100039, China. Electronic address: guoxim@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Haisong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: hdfyzhs1665@sina.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dang</LastName>
<ForeName>Ruijie</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China; Clinical Medical College, Hebei University, Yuhua Dong Road 342, Baoding, 071000, Hebei Province, China. Electronic address: powerdang@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiang</LastName>
<ForeName>Guangda</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China. Electronic address: guangda64@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Ning</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Stomatology, The First Medical Center, Chinese People's Liberation Army General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address: wenningchn@163.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Eur J Pharmacol</MedlineTA>
<NlmUniqueID>1254354</NlmUniqueID>
<ISSNLinking>0014-2999</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020880">Neuregulins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C467747">neuregulin-4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546843">mTOR protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.31</RegistryNumber>
<NameOfSubstance UI="D055372">AMP-Activated Protein Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055372" MajorTopicYN="N">AMP-Activated Protein Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050356" MajorTopicYN="N">Lipid Metabolism</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020880" MajorTopicYN="N">Neuregulins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065626" MajorTopicYN="N">Non-alcoholic Fatty Liver Disease</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AMPK</Keyword>
<Keyword MajorTopicYN="N">Aged mice</Keyword>
<Keyword MajorTopicYN="N">Autophagy</Keyword>
<Keyword MajorTopicYN="N">Hepatic steatosis</Keyword>
<Keyword MajorTopicYN="N">Neuregulin 4 (Nrg4)</Keyword>
<Keyword MajorTopicYN="N">mTOR</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>7</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>5</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32726654</ArticleId>
<ArticleId IdType="pii">S0014-2999(20)30442-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.ejphar.2020.173350</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Biao" sort="Zhu, Biao" uniqKey="Zhu B" first="Biao" last="Zhu">Biao Zhu</name>
</noRegion>
<name sortKey="Dang, Ruijie" sort="Dang, Ruijie" uniqKey="Dang R" first="Ruijie" last="Dang">Ruijie Dang</name>
<name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name>
<name sortKey="Dong, Keming" sort="Dong, Keming" uniqKey="Dong K" first="Keming" last="Dong">Keming Dong</name>
<name sortKey="Guo, Hongyan" sort="Guo, Hongyan" uniqKey="Guo H" first="Hongyan" last="Guo">Hongyan Guo</name>
<name sortKey="Guo, Shuqin" sort="Guo, Shuqin" uniqKey="Guo S" first="Shuqin" last="Guo">Shuqin Guo</name>
<name sortKey="Guo, Ximin" sort="Guo, Ximin" uniqKey="Guo X" first="Ximin" last="Guo">Ximin Guo</name>
<name sortKey="He, Mingjuan" sort="He, Mingjuan" uniqKey="He M" first="Mingjuan" last="He">Mingjuan He</name>
<name sortKey="Jiao, Ting" sort="Jiao, Ting" uniqKey="Jiao T" first="Ting" last="Jiao">Ting Jiao</name>
<name sortKey="Mei, Wen" sort="Mei, Wen" uniqKey="Mei W" first="Wen" last="Mei">Wen Mei</name>
<name sortKey="Meng, Biying" sort="Meng, Biying" uniqKey="Meng B" first="Biying" last="Meng">Biying Meng</name>
<name sortKey="Wen, Ning" sort="Wen, Ning" uniqKey="Wen N" first="Ning" last="Wen">Ning Wen</name>
<name sortKey="Xiang, Guangda" sort="Xiang, Guangda" uniqKey="Xiang G" first="Guangda" last="Xiang">Guangda Xiang</name>
<name sortKey="Xu, Xiaoli" sort="Xu, Xiaoli" uniqKey="Xu X" first="Xiaoli" last="Xu">Xiaoli Xu</name>
<name sortKey="Yang, Shuo" sort="Yang, Shuo" uniqKey="Yang S" first="Shuo" last="Yang">Shuo Yang</name>
<name sortKey="Yu, Hanying" sort="Yu, Hanying" uniqKey="Yu H" first="Hanying" last="Yu">Hanying Yu</name>
<name sortKey="Zhang, Haisong" sort="Zhang, Haisong" uniqKey="Zhang H" first="Haisong" last="Zhang">Haisong Zhang</name>
<name sortKey="Zhao, Lisheng" sort="Zhao, Lisheng" uniqKey="Zhao L" first="Lisheng" last="Zhao">Lisheng Zhao</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SuicidDentistV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000038 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000038 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SuicidDentistV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32726654
   |texte=   Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32726654" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SuicidDentistV1

This area was generated with Dilib version V0.6.39.
Data generation: Sun Oct 3 17:04:29 2021. Site generation: Sun Oct 3 17:05:17 2021

	Serveur d'exploration sur le suicide chez les dentistes
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le suicide chez les dentistes

Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.

Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki